The title “son of perdition” is used twice in the New Testament, first in John 17:12 and again in 2 Thessalonians 2:3. The phrase simply means “man doomed to destruction” and is not reserved for any one individual. In fact, there are two people to which the title “son of perdition” is applied. In context, John 17:12 is referring to Judas Iscariot, while 2 Thessalonians 2:3 is referring to the “man of lawlessness”—the Antichrist—who will appear in the end times before Christ’s return.